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Year Number of Results
1998 1
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2001 1
2003 1
2004 3
2006 2
2007 1
2008 2
2010 1
2011 3
2012 4
2013 4
2014 1
2016 3
2017 1
2018 4
2019 7
2020 3
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2023 1
2024 0

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42 results

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Page 1
Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure.
Zhu D, Zhang Z, Zhao J, Liu D, Gan L, Lau WB, Xie D, Meng Z, Yao P, Tsukuda J, Christopher TA, Lopez BL, Gao E, Koch WJ, Wang Y, Ma XL. Zhu D, et al. Circ Res. 2022 Jul 8;131(2):e34-e50. doi: 10.1161/CIRCRESAHA.121.319976. Epub 2022 May 25. Circ Res. 2022. PMID: 35611695 Free PMC article.
We recently demonstrated that AdipoR1 (APN [adiponectin] receptor 1) phosphorylation by GRK2 (G-protein-coupled receptor kinase 2) contributes to maladaptive remodeling in the ischemic heart. ...Moreover, AdipoR1(S205E) (pseudophosphorylation) phenocopied GRK2 effec …
We recently demonstrated that AdipoR1 (APN [adiponectin] receptor 1) phosphorylation by GRK2 (G-protein-coupled receptor kinase 2) co …
Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion.
Penela P, Inserte J, Ramos P, Rodriguez-Sinovas A, Garcia-Dorado D, Mayor F Jr. Penela P, et al. EBioMedicine. 2019 Oct;48:605-618. doi: 10.1016/j.ebiom.2019.09.019. Epub 2019 Oct 5. EBioMedicine. 2019. PMID: 31594751 Free PMC article.
However, whether GRK2 levels change at early time points following myocardial I/R and its functional impact during this period remain to be established. ...FINDINGS: Contrary to the maladaptive up-regulation of GRK2 reported at later times after myocardial infarctio …
However, whether GRK2 levels change at early time points following myocardial I/R and its functional impact during this period remain …
Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury.
Woodall MC, Woodall BP, Gao E, Yuan A, Koch WJ. Woodall MC, et al. Circ Res. 2016 Oct 28;119(10):1116-1127. doi: 10.1161/CIRCRESAHA.116.309538. Epub 2016 Sep 6. Circ Res. 2016. PMID: 27601479 Free PMC article.
METHODS AND RESULTS: We demonstrate, using Tamoxifen inducible, fibroblast-specific GRK2 knockout mice, that GRK2 loss confers a protective advantage over control mice after myocardial ischemia/reperfusion injury. ...GRK2 fibroblast knockout mice also had dec …
METHODS AND RESULTS: We demonstrate, using Tamoxifen inducible, fibroblast-specific GRK2 knockout mice, that GRK2 loss confers …
Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice.
Cipolletta E, Gambardella J, Fiordelisi A, Del Giudice C, Di Vaia E, Ciccarelli M, Sala M, Campiglia P, Coscioni E, Trimarco B, Sorriento D, Iaccarino G. Cipolletta E, et al. Int J Mol Sci. 2019 Mar 25;20(6):1492. doi: 10.3390/ijms20061492. Int J Mol Sci. 2019. PMID: 30934608 Free PMC article.
Using a custom peptide inhibitor of GRK2, we assessed in vitro in L6 myoblasts the effects of GRK2 inhibition on glucose extraction and insulin signaling. ...GRK2 inhibition represents a promising therapeutic target for diabetes and its cardiovascular complic …
Using a custom peptide inhibitor of GRK2, we assessed in vitro in L6 myoblasts the effects of GRK2 inhibition on glucose extra …
Lycium barbarum polysaccharide antagonizes cardiomyocyte apoptosis by inhibiting the upregulation of GRK2 induced by I/R injury, and salvage mitochondrial fission/fusion imbalance and AKT/eNOS signaling.
Li Y, Yang B, Zhang X, Shen X, Ma Y, Jing L. Li Y, et al. Cell Signal. 2022 Apr;92:110252. doi: 10.1016/j.cellsig.2022.110252. Epub 2022 Jan 19. Cell Signal. 2022. PMID: 35065240
In this study, we found that LBP limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress. G protein-coupled receptor kinase-2 (GRK2) is a key molecule involved in myocardial I/R injury. In vivo and in vitro experiments show …
In this study, we found that LBP limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress. …
G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Lai S, Fu X, Yang S, Zhang S, Lin Q, Zhang M, Chen H. Lai S, et al. J Diabetes. 2020 Mar;12(3):247-258. doi: 10.1111/1753-0407.12991. Epub 2019 Nov 3. J Diabetes. 2020. PMID: 31680450 Free PMC article.
BACKGROUND: G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial GRK2 levels are mirrored by the levels in peripheral blood mononuclear cells (PBMCs). In this study, we evaluated the myocardial and PBMC …
BACKGROUND: G protein-coupled receptor kinase-2 (GRK2) has been shown as a key regulator of cardiac function, and the myocardial G …
Chronic beta-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.
Zhu ZD, Zhang M, Wang Z, Jiang CR, Huang CJ, Cheng HJ, Guan QY, Su TT, Wang MM, Gao Y, Wu HF, Wei W, Han YS, Wang QT. Zhu ZD, et al. Acta Pharmacol Sin. 2023 Oct;44(10):1989-2003. doi: 10.1038/s41401-023-01099-2. Epub 2023 Jun 2. Acta Pharmacol Sin. 2023. PMID: 37268711
In CIA mice, treatment with the nonselective betaAR blocker carvedilol (2.5 mg.kg(-1).d(-1), for 4 weeks) or the specific GRK2 inhibitor paroxetine (2.5 mg.kg(-1).d(-1), for 4 weeks) effectively rescued heart function. We conclude that chronic and persistent beta-adrenergi …
In CIA mice, treatment with the nonselective betaAR blocker carvedilol (2.5 mg.kg(-1).d(-1), for 4 weeks) or the specific GRK2 inhibi …
A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic.
Brinks H, Das A, Koch WJ. Brinks H, et al. Future Cardiol. 2011 Jul;7(4):547-56. doi: 10.2217/fca.11.36. Future Cardiol. 2011. PMID: 21797749 Review.
This article describes the recently discovered new role of G-protein-coupled receptor kinase-2 (GRK2), which is known to critically influence the development and progression of heart failure, in acute myocardial injury. This article focuses on potential applications of the …
This article describes the recently discovered new role of G-protein-coupled receptor kinase-2 (GRK2), which is known to critically i …
Paroxetine mitigates cardiac remodelling by doxorubicin and increases survival.
Kosić M, Nešić Z, Glumac S, Vasić M, Pajović V, Savić B, Japundžić-Žigon N. Kosić M, et al. Biomed Pharmacother. 2022 Jan;145:112411. doi: 10.1016/j.biopha.2021.112411. Epub 2021 Nov 12. Biomed Pharmacother. 2022. PMID: 34781149 Free article.
DOX-treated rats exhibited bad general condition, adynamia, loss of body weight, and low survival. Echocardiography revealed two phenotypes: cardiomyopathy with left ventricular (LV) hypertrophy (DOX-HCM) and cardiomyopathy with LV dilation (DOX-DCM). ...In these ra …
DOX-treated rats exhibited bad general condition, adynamia, loss of body weight, and low survival. Echocardiography revealed two phenotypes: …
Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2.
Aluja D, Inserte J, Penela P, Ramos P, Ribas C, Iñiguez MÁ, Mayor F Jr, Garcia-Dorado D. Aluja D, et al. Basic Res Cardiol. 2019 Mar 26;114(3):21. doi: 10.1007/s00395-019-0730-5. Basic Res Cardiol. 2019. PMID: 30915659 Free article.
Recent data suggest that calpain activity is elevated in non-ischemic cardiomyopathies and that upregulation of the key cardiac G-protein-coupled receptor kinase 2 (GRK2) signaling hub promotes cardiac hypertrophy. ...GRK2 upregulation was associated to calpa …
Recent data suggest that calpain activity is elevated in non-ischemic cardiomyopathies and that upregulation of the key cardiac G-pro …
42 results